The A5 Douglas Road north of Ballasalla was closed for around two and a half hours following a road traffic collision.
Emergency services were called to the scene of the two-vehicle collision at just after 8.15pm on Saturday evening.
Police confirmed that the incident involved a car and a van.
Fire crews extricated one casualty from the car who was transferred to Noble’s Hospital with non-life threatening injuries. They remain in hospital.
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The A5 was closed between the Reayrt Mie roundabout and the Blackboards junction with Old Castletown Road while police investigated the incident and to enable the carriageway to be cleared.
Orrisdale Road was also closed from its junction at St Mark’s Road to the Douglas Road except for access to properties.
The roads reopened just before 11pm.