Emergency services are currently responding to a crash near St Marks.
As a result, a road closure has been implemented between St Marks Crossroads and Clanna Road Crossroads.
The Isle of Man Constabulary is advising motorists and the general public to avoid the area as the closure is expected to remain in place for some time.
No further details regarding the nature of the collision have been released at this time.
Follow our live blog below for the latest updates relating to the incident.