Ronaldsway Met Office has issued a weather alert as frost and icy conditions are expected overnight.
The yellow weather warning will come into force at 3am on Thursday and will last until 11am the same day.
While temperatures will only fall to 3C on lower ground, there is a risk of ice on hills and roads higher up.
A Met Office spokesperson said: ‘Road temperatures are likely to fall close to or slightly below zero later tonight and at first tomorrow on high level roads (mainly above 500 feet).
‘However, the majority of surfaces will stay dry, with any ice only where there is pre-existing moisture.’
The cold weather is likely to stick around with highs of only 6C on Thursday and Friday while strong winds will also arrive which could result in coastal topping in places during high tide.
It will be slightly warmer at the weekend but there will still be highs of only 7C and strong winds persisting.